BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
نویسندگان
چکیده
منابع مشابه
BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.
Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. A major question has been why BRCA1 loss or mutation leads to tumors mainly in estrogen-regulated tissues, given that BRCA1 has essential functions in all cell types....
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1 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, 2 Institute of Medical Engineering and Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Bosto...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2014
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-13-2611